Cognitive dysfunctions and pathological gambling in patients with Parkinson's disease
Identifieur interne : 000577 ( Main/Corpus ); précédent : 000576; suivant : 000578Cognitive dysfunctions and pathological gambling in patients with Parkinson's disease
Auteurs : Gabriella Santangelo ; Carmine Vitale ; Luigi Trojano ; Francesca Verde ; Dario Grossi ; Paolo BaroneSource :
- Movement Disorders [ 0885-3185 ] ; 2009-04-30.
English descriptors
Abstract
The purpose of this study was to investigate the neuropsychological correlates of pathological gambling (PG) in Parkinson's disease (PD). Fifteen patients with PD affected by PG (identified based on DSM‐IV criteria; PD+PG) without clinically evident dementia were compared with 15 nondemented patients with PD not affected by PG (PD−PG). Two groups of patients with PD were matched for age, length of education, and gender. Clinical and neuropsychiatric features were assessed; several cognitive domains, mainly related to executive functions, were explored by means of standardized neuropsychological tasks. PD+PG and PD−PG did not differ on clinical and neuropsychiatric aspects. PD+PG patients performed significantly worse than PD−PG patients on cognitive tasks that evaluated visuo‐spatial long‐term memory and several frontal lobe functions. After Bonferroni correction, differences remained significant on the Frontal Assessment Battery (FAB) (P = 0.001), on phonological fluency task (P = 0.003), and on the Trail Making Test, part B minus part A (P = 0.002). Logistic regression analysis demonstrated that low scores on the FAB were the only independent predictor of PG (odds ratio, 27.9; 95% CI: 2.82–277.95, P = 0.004). The results indicate an association between PG and frontal lobe dysfunctions in nondemented patients with PD. Low scores on the FAB indicate patients with PD at high risk for PG. © 2009 Movement Disorder Society
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DOI: 10.1002/mds.22472
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Italy</mods:affiliation></affiliation></author><author><name sortKey="Barone, Paolo" sort="Barone, Paolo" uniqKey="Barone P" first="Paolo" last="Barone">Paolo Barone</name><affiliation><mods:affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. 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Fifteen patients with PD affected by PG (identified based on DSM‐IV criteria; PD+PG) without clinically evident dementia were compared with 15 nondemented patients with PD not affected by PG (PD−PG). Two groups of patients with PD were matched for age, length of education, and gender. Clinical and neuropsychiatric features were assessed; several cognitive domains, mainly related to executive functions, were explored by means of standardized neuropsychological tasks. PD+PG and PD−PG did not differ on clinical and neuropsychiatric aspects. PD+PG patients performed significantly worse than PD−PG patients on cognitive tasks that evaluated visuo‐spatial long‐term memory and several frontal lobe functions. After Bonferroni correction, differences remained significant on the Frontal Assessment Battery (FAB) (P = 0.001), on phonological fluency task (P = 0.003), and on the Trail Making Test, part B minus part A (P = 0.002). Logistic regression analysis demonstrated that low scores on the FAB were the only independent predictor of PG (odds ratio, 27.9; 95% CI: 2.82–277.95, P = 0.004). The results indicate an association between PG and frontal lobe dysfunctions in nondemented patients with PD. Low scores on the FAB indicate patients with PD at high risk for PG. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Gabriella Santangelo PhD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</json:string><json:string>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</json:string><json:string>Istituto di Diagnosi e Cura “Hermitage Capodimonte,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Carmine Vitale MD, PhD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</json:string><json:string>Istituto di Diagnosi e Cura “Hermitage Capodimonte,” Naples, Italy</json:string></affiliations></json:item><json:item><name>Luigi Trojano MD</name><affiliations><json:string>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</json:string></affiliations></json:item><json:item><name>Francesca Verde PhD</name><affiliations><json:string>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</json:string></affiliations></json:item><json:item><name>Dario Grossi MD</name><affiliations><json:string>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</json:string></affiliations></json:item><json:item><name>Paolo Barone MD, PhD</name><affiliations><json:string>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>pathological gambling</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>executive functions</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>frontal lobe</value></json:item></subject><articleId><json:string>MDS22472</json:string></articleId><language><json:string>eng</json:string></language><abstract>The purpose of this study was to investigate the neuropsychological correlates of pathological gambling (PG) in Parkinson's disease (PD). Fifteen patients with PD affected by PG (identified based on DSM‐IV criteria; PD+PG) without clinically evident dementia were compared with 15 nondemented patients with PD not affected by PG (PD−PG). Two groups of patients with PD were matched for age, length of education, and gender. Clinical and neuropsychiatric features were assessed; several cognitive domains, mainly related to executive functions, were explored by means of standardized neuropsychological tasks. PD+PG and PD−PG did not differ on clinical and neuropsychiatric aspects. PD+PG patients performed significantly worse than PD−PG patients on cognitive tasks that evaluated visuo‐spatial long‐term memory and several frontal lobe functions. After Bonferroni correction, differences remained significant on the Frontal Assessment Battery (FAB) (P = 0.001), on phonological fluency task (P = 0.003), and on the Trail Making Test, part B minus part A (P = 0.002). Logistic regression analysis demonstrated that low scores on the FAB were the only independent predictor of PG (odds ratio, 27.9; 95% CI: 2.82–277.95, P = 0.004). The results indicate an association between PG and frontal lobe dysfunctions in nondemented patients with PD. 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Logistic regression analysis demonstrated that low scores on the FAB were the only independent predictor of PG (odds ratio, 27.9; 95% CI: 2.82–277.95, P = 0.004). The results indicate an association between PG and frontal lobe dysfunctions in nondemented patients with PD. 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Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="60"><doi origin="wiley" registered="yes">10.1002/mds.v24:6</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">6</numbering></numberingGroup><coverDate startDate="2009-04-30">30 April 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="150" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22472</doi><idGroup><id type="unit" value="MDS22472"></id></idGroup><countGroup><count type="pageTotal" number="7"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="thirdParty">Copyright © 2009 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2008-05-23"></event><event type="manuscriptRevised" date="2008-11-17"></event><event type="manuscriptAccepted" date="2008-12-29"></event><event type="publishedOnlineEarlyUnpaginated" date="2009-02-09"></event><event type="firstOnline" date="2009-02-09"></event><event type="publishedOnlineFinalForm" date="2009-04-24"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.6 mode:FullText source:FullText result:FullText" date="2010-04-20"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-02"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">899</numbering><numbering type="pageLast">905</numbering></numberingGroup><correspondenceTo>Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22472.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="3"></count><count type="referenceTotal" number="60"></count><count type="wordTotal" number="5501"></count></countGroup><titleGroup><title type="main" xml:lang="en">Cognitive dysfunctions and pathological gambling in patients with Parkinson's disease<link href="#fn1"></link></title><title type="short" xml:lang="en">Pathological Gambling, Frontal Function in PD</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2 #af3"><personName><givenNames>Gabriella</givenNames><familyName>Santangelo</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Carmine</givenNames><familyName>Vitale</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Luigi</givenNames><familyName>Trojano</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Francesca</givenNames><familyName>Verde</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Dario</givenNames><familyName>Grossi</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>Paolo</givenNames><familyName>Barone</familyName><degrees>MD, PhD</degrees></personName><contactDetails><email>barone@unina.it</email></contactDetails></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="IT" type="organization"><unparsedAffiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="IT" type="organization"><unparsedAffiliation>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="IT" type="organization"><unparsedAffiliation>Istituto di Diagnosi e Cura “Hermitage Capodimonte,” Naples, Italy</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">pathological gambling</keyword><keyword xml:id="kwd2">Parkinson's disease</keyword><keyword xml:id="kwd3">executive functions</keyword><keyword xml:id="kwd4">frontal lobe</keyword></keywordGroup><fundingInfo><fundingAgency>Ministry of Health</fundingAgency></fundingInfo><fundingInfo><fundingAgency>IRCCS Don Gnocchi</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The purpose of this study was to investigate the neuropsychological correlates of pathological gambling (PG) in Parkinson's disease (PD). Fifteen patients with PD affected by PG (identified based on DSM‐IV criteria; PD+PG) without clinically evident dementia were compared with 15 nondemented patients with PD not affected by PG (PD−PG). Two groups of patients with PD were matched for age, length of education, and gender. Clinical and neuropsychiatric features were assessed; several cognitive domains, mainly related to executive functions, were explored by means of standardized neuropsychological tasks. PD+PG and PD−PG did not differ on clinical and neuropsychiatric aspects. PD+PG patients performed significantly worse than PD−PG patients on cognitive tasks that evaluated visuo‐spatial long‐term memory and several frontal lobe functions. After Bonferroni correction, differences remained significant on the Frontal Assessment Battery (FAB) (<i>P</i> = 0.001), on phonological fluency task (<i>P</i> = 0.003), and on the Trail Making Test, part B minus part A (<i>P</i> = 0.002). Logistic regression analysis demonstrated that low scores on the FAB were the only independent predictor of PG (odds ratio, 27.9; 95% CI: 2.82–277.95, <i>P</i> = 0.004). The results indicate an association between PG and frontal lobe dysfunctions in nondemented patients with PD. Low scores on the FAB indicate patients with PD at high risk for PG. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: Nothing to report.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Cognitive dysfunctions and pathological gambling in patients with Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Pathological Gambling, Frontal Function in PD</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Cognitive dysfunctions and pathological gambling in patients with Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Gabriella</namePart><namePart type="family">Santangelo</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</affiliation><affiliation>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</affiliation><affiliation>Istituto di Diagnosi e Cura “Hermitage Capodimonte,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Carmine</namePart><namePart type="family">Vitale</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</affiliation><affiliation>Istituto di Diagnosi e Cura “Hermitage Capodimonte,” Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luigi</namePart><namePart type="family">Trojano</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Francesca</namePart><namePart type="family">Verde</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dario</namePart><namePart type="family">Grossi</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Laboratorio di Neuropsicologia, Dipartimento di Psicologia, Seconda Università Studi di Napoli, Naples, Italy</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paolo</namePart><namePart type="family">Barone</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Dipartimento di Scienze Neurologiche, Università di Napoli Federico II, Naples, Italy</affiliation><description>Correspondence: Department of Neurological Sciences, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-04-30</dateIssued><dateCaptured encoding="w3cdtf">2008-05-23</dateCaptured><dateValid encoding="w3cdtf">2008-12-29</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">3</extent><extent unit="references">60</extent><extent unit="words">5501</extent></physicalDescription><abstract lang="en">The purpose of this study was to investigate the neuropsychological correlates of pathological gambling (PG) in Parkinson's disease (PD). Fifteen patients with PD affected by PG (identified based on DSM‐IV criteria; PD+PG) without clinically evident dementia were compared with 15 nondemented patients with PD not affected by PG (PD−PG). Two groups of patients with PD were matched for age, length of education, and gender. Clinical and neuropsychiatric features were assessed; several cognitive domains, mainly related to executive functions, were explored by means of standardized neuropsychological tasks. PD+PG and PD−PG did not differ on clinical and neuropsychiatric aspects. PD+PG patients performed significantly worse than PD−PG patients on cognitive tasks that evaluated visuo‐spatial long‐term memory and several frontal lobe functions. After Bonferroni correction, differences remained significant on the Frontal Assessment Battery (FAB) (P = 0.001), on phonological fluency task (P = 0.003), and on the Trail Making Test, part B minus part A (P = 0.002). Logistic regression analysis demonstrated that low scores on the FAB were the only independent predictor of PG (odds ratio, 27.9; 95% CI: 2.82–277.95, P = 0.004). The results indicate an association between PG and frontal lobe dysfunctions in nondemented patients with PD. Low scores on the FAB indicate patients with PD at high risk for PG. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: Nothing to report.</note><note type="funding">Ministry of Health</note><note type="funding">IRCCS Don Gnocchi</note><subject lang="en"><genre>Keywords</genre><topic>pathological gambling</topic><topic>Parkinson's disease</topic><topic>executive functions</topic><topic>frontal lobe</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><subject><genre>article category</genre><topic>Research Article</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>899</start><end>905</end><total>7</total></extent></part></relatedItem><identifier type="istex">B11ECA2CF47A6B8F4FBAB0D7C2E2CAFD00AA7F9B</identifier><identifier type="DOI">10.1002/mds.22472</identifier><identifier type="ArticleID">MDS22472</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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